Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.
نویسندگان
چکیده
We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.
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عنوان ژورنال:
- Infection and immunity
دوره 61 11 شماره
صفحات -
تاریخ انتشار 1993